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Which prefixes signify the meaning "around"?

  1. epi- and sub-

  2. peri- and circum-

  3. sub- and infra-

  4. infra- and peri-

The correct answer is: peri- and circum-

Both "peri-" and "circum-" are prefixes that indicate the meaning "around." "Peri-" originates from the Greek term meaning "around" or "surrounding," and is commonly used in medical terminology to describe structures or conditions that encircle or are located around a specific area, such as "pericardium," which refers to the membrane surrounding the heart. "Circum-" also comes from Latin, meaning "around" or "about," often used in terms like "circumference," which refers to the distance around a circle. In medical contexts, it is seen in words like "circumcision," which involves cutting around the foreskin. Both of these prefixes effectively convey the concept of surrounding or encircling an object or area, making them appropriate choices to signify "around."